Estrogen Replacement : Natural Hormones vs. Synthetics

Synthetics: Why Be Concerned With Synthetic Hormones?

Pharmaceutical companies make most of the estrogen products available to women. The objective is to produce a formula that can be patented. That means adding something to the hormone that makes it different and patentable. The patent defines the product that can be promoted to doctors. Because the product never changes, insurance companies can give it a number (dae) and negotiate a price it will pay. In other words, it fits the system. For women it means one size must fit all.

Intro estrogen image from


Synthetic estrogens are based primarily on the aggressive estradiol (E2)and or estrone (E1). They provide a simple approach to effecting the major symptoms of menopause. The addition of synthetic materials also produces complications and side effects such as headaches, muscle cramps, fatigue and increased risk of cancer. As a result, statistics indicate that 50% of patients who use the synthetic hormones prescribed, less than 40% continue beyond one year.

Estrogen infographic from

Natural Estrogen

Natural estrogens come from plant sources and are molecularly equal (bio-identicle) to what is produced by and exists in a woman’s body. We are convinced natural hormones are safe. Natural estrogens can be purchased in two ways:

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1. Phyto-estrogen supplement (non-prescription). This may be an excellent alternative for women in early pre-menopause, prior to needing prescription strength hormones (Remember to use this with a topical non-prescription progesterone). See Estro-Flavone.

2. Prescription through a compounding pharmacy. This is where we can be of help to you. Natural estrogens cannot be patented and are therefore of no interest to pharmaceutical companies. Because they are mixed by a compounding pharmacy tailored to a woman’s needs, insurance companies may not favor them.

We can help you locate a physician in your area who prescribes natural hormones. We can also fill you prescriptions once you have them written.

Examine Facts By Comparison

Typical synthetic: 60% – 70% estradiol: 40% – 30% estrone
Natural formula: (Tri-est): 80% estriol: 10% estradiol: 10% estrone

The doctor who cares and is willing to take the time will use a mixture of estrogens tailored to each woman’s needs. The probable result is a menopause virtually free of symptoms.

Estrogen Summary

As a woman enters pre-menopause, healthy levels of estrogen is critical to good health. Natural estrogen replacement is the choice of women who want a safe and healthy revitalization of their youth.


Natural progesterone is produced by the ovaries. It plays a major role in conception. As a woman enters the time of peri-menopause, progesterone provides a major protective function. It is sometimes referred to as the “hormone harmonizer” or the “estrogen shock absorber”.

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The body manufactures large amounts during pregnancy. In a normal 28-day cycle, barely any progesterone is produced during the first two weeks. After ovulation, it kicks in and lasts for two weeks.

Progesterone infographic from

In the life cycle, progesterone generally starts to decline in the mid-thirties and that decline accelerates dramatically in the forties. A woman who has achieved total menopause has only a minute amount of progesterone, grossly insufficient to protect against the threat of osteoporosis.

The overall reduction of progesterone is earlier, more rapid and persistent than the decline of estrogen. Its decline leaves the body vulnerable to the consequences of estrogen dominance — a common problem in this day of synthetic estrogens.

Progesterone image from

Progesterone : What does it do?

  • Protects against estrogen dominance (see Estrogen)
  • Helps protect the breasts, uterus and ovaries from cancer
  • Anti-anxiety effect
  • Prevents water retention
  • Improves breakdown of fat into energy by raising thyroid hormone levels. This same action also helps reduce hair loss.
  • Reduces hair loss by blocking conversion of testosterone to DHT
  • Cuts craving for carbohydrates
  • Reduces breast tenderness
  • Contributes to new bone tissue
  • Increases HDL- the good cholesterol

Natural Progesterone vs Synthetic

What is true of synthetic estrogen is also true of synthetic progesterone (Progestins). Pharmaceutical companies will not produce natural progesterone because it can not be patented. Progestins are dangerous.

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Natural vs Synthetic image from

Synthetic progesterone: negative side effects

Is a coronary constrictive that reduces the diameter of the veins leading to the heart

  • Contributes to insulin resistance
  • Contributes to breast cancer
  • Undermines the protective benefits of estrogen related to plaque formation and cholesterol oxidation
  • Promotes fluid retention
  • Promotes breakthrough bleeding
  • Contributes to hair loss
  • Dr. John Lee, who has written several books on the subject of natural progesterone therapy, in a recent newsletter stated; “using synthetic progesterone for menopausal women should be considered medical malpractice”.

Suggested dose: Minimum 50mg/day to as high as 300mg/day depending on symptoms. Cycling women should take progesterone the last two weeks of their cycle.

Progesterone Summary

Natural progesterone is true progesterone. Its replacement can be very beneficial to a woman’s health. Synthetics are actually drugs and can negatively affect a woman’s health.

I’m a sex enthusiast, published fantasy writer and the editing director of Brewin’ After Dark. I write about topics surrounding sexual health. Thanks for reading and add me on Twitter!

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